The monoaminergic system consists of a dynamic network of neurons located in the brainstem with widely branches ensuring the monoamine neurotransmitters act in most part of the brain. The monoamine neurotransmitters, dopamine, noradrenaline, and serotonin play a pivotal role in many important physiological functions including attention, mood, motivation, pain sensation, arousal, and sexual function. The levels of monoamines can be regulated in the synaptic cleft by inhibition of monoamine transporters or by inhibition of the degradation with monoamine oxidase inhibitors. Medications with these properties are used to treat depression, attention deficit hyperactive disorder (ADHD), narcolepsy, anxiety, pain, and Parkinson´s disease. Several of these medications have improved the treatment of the diseases, but may also be associated with lack of effect in a fraction of patients and with adverse effects. To address the unmet need and to avoid adverse effects, Initiator Pharma A/S has developed a series of inhibitors of mono-amine transporters with unique profiles for the three mono-amine transporters and an attractive safety profile. The different profiles of the drug candidates for inhibition of the MATs in our pipeline allow targeting specific diseases, e.g., so far erectile dysfunction of organic origin, erectile dysfunction of psychogenic origin, and pain.

Fun facts

  • Dopamine is a strong neurotransmitter in the brain. Also called the “feel good hormone”, dopamine determines how we feel pleasure. Foods can actually give you dopamine boosts! Foods (like cheese, nuts, and chicken) that have L-Tyrosine and L-Phenylalanine increase levels of dopamine because they convert into dopamine.
  • Research has shown that dopamine and serotonin increase during massages, and cortisol (the “stress hormone”) decreases.
  • Chocolate can help increase serotonin levels and happiness